Regulatory forum opinion piece: the role of the toxicologic pathologist in the postgenomic era: challenges and opportunities.

Regulatory forum opinion piece: the role of the toxicologic pathologist in the postgenomic era: challenges and opportunities.

The “omics,” high-throughput screening, computational modeling, and database mining revolutions have every arrived with euphoric expectations, appreciable hand waving, and guarantees to set toxicity testing priorities and scale back reliance on standard animal toxicity and carcinogenicity testing. Reflecting again on prior expertise with different predictive approaches and options, what follows the frenzy to endorse a […]

Continue Reading
What Is New about the Exposome? Exploring Scientific Change in Contemporary Epidemiology.

What Is New about the Exposome? Exploring Scientific Change in Contemporary Epidemiology.

On this commentary, I focus on the scientific modifications introduced by the exposome, asking what’s new about this method and line of analysis. I place the exposome in a historic perspective, by analyzing the circumstances below which the exposome has been conceived, developed and established within the context of latest epidemiological analysis. I argue that […]

Continue Reading
Automated Cell-Free Multiprotein Synthesis Facilitates the Identification of a Secretory, Oligopeptide Elicitor-Like, Immunoreactive Protein of the Oomycete Pythium insidiosum.

Automated Cell-Free Multiprotein Synthesis Facilitates the Identification of a Secretory, Oligopeptide Elicitor-Like, Immunoreactive Protein of the Oomycete Pythium insidiosum.

Protein manufacturing depends on time-consuming genetic engineering and in vivo expression, which is a bottleneck for purposeful research within the postgenomic period. Cell-free protein synthesis (CFPS) overcomes the limitation of in vivo protein biosynthesis by processing in vitro transcription and translation of a number of genes to proteins inside hours. We employed an automatic CFPS to concurrently synthesize proteins from 24 genes of […]

Continue Reading
Rice protein-binding microarrays: a tool to detect cis-acting elements near promoter regions in rice

Rice protein-binding microarrays: a tool to detect cis-acting elements near promoter regions in rice

The current examine confirmed {that a} rice (Oryza sativa)-specific protein-binding microarray (RPBM) will be utilized to investigate DNA-binding motifs with a TF the place binding is evaluated in prolonged pure promoter areas. The evaluation might facilitate figuring out TFs and their downstream genes and developing gene networks by cis-elements. Transcription elements (TFs) regulate gene expression […]

Continue Reading
The application of omics in ruminant production: a review in the tropical and sub-tropical animal production context

The application of omics in ruminant production: a review in the tropical and sub-tropical animal production context

The demand for animal merchandise (e.g. dairy and beef) in tropical areas is predicted to extend in parallel with the general public demand for sustainable practices, attributable to components akin to inhabitants progress and local weather change. The need to extend animal manufacturing output should be achieved with higher administration and manufacturing applied sciences. For […]

Continue Reading